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# Mental health and biology
- URL: https://www.gilespcroft.com/mental-health-and-biology/
- Published: 2026-05-14T06:00:06.000Z
- Updated: 2026-08-08T14:55:16.000Z
- Description: Exploring the relationship between brain biology & mental health 🧠
- Author: Giles P Croft
- Tags: Neuroscience, Mental Health, Thought realisation, Real stories, Psychology, Medicine, IMPLICATIONS, Comics

When I first came across the Innate Health understanding (there's a lengthy, [4-part story about that here](https://www.gilespcroft.com/tag/insight-series/), if you're curious), things changed for me considerably, and I saw pretty much all of life quite differently.

Except mental health conditions.

See, I'd done a psychology degree, gone to medical school, worked as a doctor (even considering Psychiatry at one point) and basically been indoctrinated into the medical model of mental health *so* comprehensively, that when I heard people like 3Ps [Psychiatrist Dr Bill Pettit](https://gilespcroft.link/bill-pettit/?ref=gilespcroft.com) saying things like,

> *“There's only one cause of mental illness, and therefore one cure”*

…well, I just dismissed it out of hand. Because I (i.e. the Giles Ego Construct 📦) knew **for a fact** that it was more complicated than that. I'd read textbooks, had training, hell, even got qualifications that supported a much more granular view! 

I also, very understandably, subscribed to the widely-held view that things like depression were caused by a deficiency in brain serotonin, because—again—that's what I'd been taught, over and over again, and I never thought to question it. ([It's not true](https://www.nature.com/articles/s41380-022-01661-0?ref=gilespcroft.com).)

The first time I listened to Dr Bill Pettit being interviewed on a podcast, I switched it off half way through, somewhat disappointed that 3 Principles teachers I trusted were having conversations with someone who was clearly [deluded](https://www.gilespcroft.com/were-all-deluded/), when it came to mental health.

😂

Ha ha! I can laugh now, having met Bill, been on courses with him and immersed myself more deeply in the Innate health understanding. Because I can see how the simplicity—the ‘one cause’ aspect he talks about—doesn't so much replace, or negate the complexity that we see in human behaviours & symptoms, it just lies [upstream of it all](https://www.gilespcroft.com/looking-upstream/), giving rise to it all.

Still, my poor medically-trained Thought System couldn't seem to get past the difficulty of biochemical changes in the brain surely *causing* different thoughts, feelings and behaviours? (I'd drunk enough alcohol in my life to have seen how *that* works! 😆)

It couldn't be the other way round, could it? Thought *couldn't* cause changes in our biology… could it?

Until one of those 3 Principles teachers I trusted pointed out something as simple as embarrassment, or anger—i.e. thought/feeling constructs—causing profound physiological changes within us.

🤷🏻‍♂️

I recently came across this joyfully cheeky little episode of the [Sufi Comics strip](https://www.suficomics.com/blog/whats-in-a-name?ref=gilespcroft.com), that—in a slightly different context—spells out the same thing:

[![](https://storage.ghost.io/c/9b/f3/9bf3d316-7d32-494b-814f-a7d94d6358c3/content/images/2026/05/2026-05-14-Mental-health-and-biology.jpg)](https://www.suficomics.com/blog/whats-in-a-name?ref=gilespcroft.com)

Read the full thing, here → [https://www.suficomics.com/blog/whats-in-a-name](https://www.suficomics.com/blog/whats-in-a-name?ref=gilespcroft.com)

When I slowed down and reflected that a room full of people could have a range of reactions to all sorts of situations, all of which could easily be accompanied by physiological changes, it just started to loosen my sense of ‘rightness’; of ‘knowing for a fact’ that things were indeed the way I'd been taught for so many years.

Who was I to say that repeated habits of thinking couldn't affect biochemistry over time, or cause long term organic changes in the body and/or brain, or even switch genes off and on?

I still don't know, but I'm a lot more comfortable not knowing these days.

I certainly don't proclaim to know much of anything ‘for a fact’ any more, and I have to say, life's become a lot less aggro, since!

✌🏻

Giles

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### Related

[Unknown unknownsThe thing that’s going to help you change lies outside of your current frame of reference ✨![](https://storage.ghost.io/c/9b/f3/9bf3d316-7d32-494b-814f-a7d94d6358c3/content/images/icon/DR_Lockup-Black-3-521.png)The Daily RemindersGiles P Croft![](https://storage.ghost.io/c/9b/f3/9bf3d316-7d32-494b-814f-a7d94d6358c3/content/images/thumbnail/2026-18-03-Unknown-Unknowns_Thought-System-Box-1-1.jpg)](https://www.gilespcroft.com/unknown-unknowns/)

You could fit the sum total of everything I don't know into the infinite void of the universe.